A transformational approach for allergies to cats
For the first time in history, Purina scientists have demonstrated a proactive way to significantly reduce the active levels of Fel d1 by taking advantage of the antibody-allergen interaction to neutralize Fel d1 after its production by the cat, but before it is spread into the environment. Anti-Fel d1 IgY antibodies bind and neutralize Fel d1, preventing it from binding to IgE in a Fel d1-sensitized individual.
Purina’s research showed when cats were fed a diet with an egg product ingredient containing anti-Fel d1 IgY, 97% showed decreased levels of active Fel d1 on their hair and dander. (“Active” Fel d1 is Fel d1 that is capable of binding to IgE and triggering an allergic response in sensitized individuals).22
On average, there was a 47% reduction of active Fel d1 on cats’ hair after 3 weeks of feeding the diet.23
Additionally, 86% of cats had a reduction of at least 30% from baseline levels.23
This ultimately reduces active Fel d1 levels in the environment. Cat-allergic people exposed to dander from cats fed a diet with anti-Fel d1 IgY showed significant reductions in nasal allergy symptoms and some ocular symptoms.24
The ingredient is safe for cats, based on a comprehensive safety study that fed an egg product ingredient with multiple levels of anti-Fel d1 IgY, including levels many times higher than those used in our studies.25
Change the conversation. Keep the cat.
Cat owners with allergies to cats face a difficult conversation with an allergist or veterinarian who might recommend rehoming the cat. Because of Purina’s transformational approach to managing these allergies, now they can have a different conversation — one that helps keep cats in loving homes.
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- Satyaraj, E., Li, Q., Sun, P. & Sherrill, S. (2019). Anti-Fel d1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva. Accepted for publication, Journal of Feline Medicine and Surgery.
- Satyaraj, E., Gardner, C., Filipi, I., Cramer, K. & Sherrill, S. (2019). Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. Immunity, Inflammation & Disease. Advanced online publication. doi:10.1002/iid3.244
- Wedner, J., Satyaraj, E., Gardner, C., Al-Hammadi, N., Sherrill, S. & Mantia, T. (2019, June) Pilot study to determine effect of feeding cat food made with egg product containing anti-Fel d1 antibodies to cats on human allergy symptoms. Presented at the annual meeting of the European Academy of Allergy and Clinical Immunology, Lisbon, Portugal.
- Matulka, R. A., Thompson, L. & Corley, D. (2019). Evaluation of a multi-level safety study of anti-Fel d1 IgY. Submitted, Journal of Food and Chemical Toxicology.