Ludovic graduated from the École Nationale Vétérinaire d'Alfort (Paris, France) in 2001, where he completed a two-year small animal internal medicine internship. He then completed a 3-year anaesthesia residency at the Royal Veterinary College (RVC), London, UK where he gained his European Diploma of Veterinary Anaesthesia and Anaesthesia in 2006.
Ludovic completed his pharmacology PhD at the RVC in 2010 on the roles of cyclooxygenase (COX) isoenzymes in the regulation of inflammation and the renal function in the cat
(supervised by Professor Jonathan Elliott and Professor Peter Lees and Dr. Jon King, Novartis).
Ludovic has been back in the clinics as a senior anesthetist since the end of his PhD. He is now a Senior Lecturer in Veterinary Clinical Pharmacology and Anaesthesia. He is co-head of the RVC anaesthesia /analgesia service operating in the different RVC referral hospitals. He enjoys running the busy service, teaching students and anaesthesia residents and dealing with anaesthetic challenges.
Ludovic gained the European Diploma in Veterinary Pharmacology and Toxicology in 2014.
Ludovic's main research interests is pharmacology of analgesics, in particular NSAIDs and other drugs in species of veterinary interest (cats, dogs, horses, calves but also more exotic species such as emus or salamanders). He is developing research programs in pharmacology and pain management (acute and chronic), particularly in the area of pharmacokinetics and mathematical modeling (PK-PD). Ludovic is a core founding member and the webmaster of the Animal Health Modelling and Simulation Society.
Ludovic is promoting the use of pharmacometrics to help resolve clinical questions at the level of the invidual animal or for more global questions, as in the field of antimicrobial use and resistance. Ludovic is in the steering committee of VetCAST
, the veterinary subcommittee of the European Committee on Antimicrobial Susceptibility Testing (EUCAST).
Ludovic collaborates in his research with colleagues from the RVC and has established solid research, consultancy or business relationships with external companies such as detlaDOT Ltd
. Ludovic is striving to expand the RVC analytical laboratory to support veterinary a therapeutic drug monitoring service and drug development schemes in collaboration with deltaDOT Ltd. A iohexol clearance test is available to monitor glomerular filtration
rate (GFR) in dogs and cats (clinical or research).
- Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. CPT Pharmacometrics Syst Pharmacol. 2016 Oct 22.
- Veterinary Medicine Needs New Green Antimicrobial Drugs. Toutain PL, Ferran AA, Bousquet-Melou A, Pelligand L, Lees P. Front Microbiol. 2016 Aug 3;7:1196.
- Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf. Toutain PL, Potter T, Pelligand L, Lacroix M, Illambas J, Lees P. J Vet Pharmacol Ther. 2016 Aug 8. doi: 10.1111/jvp.12333. [Epub ahead of print]
- Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney. Pelligand L, Suemanotham N, King JN, Seewald W, Syme H, Smith K, Lees P, Elliott J. BMC Vet Res. 2015 Dec 3;11:296
- Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation. Pelligand L, King JN, Hormazabal V, Toutain PL, Elliott J, Lees P. J Vet Pharmacol Ther. 2014 2014 Aug;37(4):354-66