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Liver Standardization Project

The aim of the Liver Standardization Project is to obtain worldwide standardization for histological evaluation of liver tissues for liver diseases of dogs and cats: unified nomenclature, well-defined histological diagnostic criteria, and precise definition of chronicity stages and grades of diseases. Also, requirements for tissue staining techniques and size of tissue specimens are being recommended for the different diseases. Descriptions and typical slides of all relevant liver diseases of dogs and cats become available as a reference for all veterinarians. Of course liver diagnostics is not only a matter of histopathology. Therefore, the relation with clinical and laboratory findings will be indicated when necessary. All this information will be published in a book, which will be available at an affordable price to make it widely available for all interested veterinarians and other potential users.

Our Members

  • Dr. S. Bunch (USA), clinical hepatologist.
  • Dr. J. Charles (Australia), liver pathologist.
  • Dr. J. Cullen (USA), liver pathologist.
  • Dr. V.J. Desmet (Europe, Belgium), human liver pathologist.
  • Dr. T. van den Ingh (Europe, Netherlands), liver pathologist.
  • Dr. T. VanWinkle (USA), liver pathologist.
  • Dr. D. Twedt (USA), clinical hepatologist.
  • Dr. R. Washabau (USA), gastroenterologist/hepatologist/ACVIM
  • Dr. J. Rothuizen (Europe, Netherlands), clinical hepatologist, coordinator of the Group.


  • WSAVA Standards for Histological and Clinical Diagnosis of Canine and Feline Liver Diseases.  
    • In a publishing partnership with Elsevier, WSAVA is proud to announce the availability of the WSAVA Standards for Histological and Clinical Diagnosis of Canine and Feline Liver Diseases, representing a culmination of efforts begun in 2000 and prompted by discussions between then WSAVA president Hans-Klaus Dreier, president-elect Claudio Brovida, and Dr. Jan Rothuizen of Utrecht University. Born from a WSAVA strategic initiative to strengthen the relationship between veterinary academia and veterinary medical associations, this project is the first in a series of standardization initiatives begun by the WSAVA in an effort to provide clear direction in areas of academic research that have a direct impact on the practice of veterinary medicine.
    • Chapters include:
      • Sampling and handling of liver tissue.
      • Ultrasonographic identification and characterization of congenital portosystemic shunts and portal hypertensive disorders.
      • Morphological classification of biliary disorders.
      • Hepatic abscesses and granulomas, hepatic metabolic storage diseases, and miscellaneous conditions.

View the WSAVA Liver Disease Guidelines.